| The immunosuppressive impact of PRRS virus on the immune response following anti-erysipelas vaccination in swine from various farms Viorica Chiurciu, Costin Stoica, Maria Mioara Răduţă, Cătălin Tudoran, Diaconu Lucia, Ion Iacob SC Romvac Company SA, Voluntari, Romania |
Abstract
The PRRS virus, the etiologic agent of the Porcine Respiratory and Reproductive Syndrome, due to
its immunosuppressive effect can significantly impair the postvaccinal immune response.
The immunological reaction induced by anti-erysipelas vaccination has been observed both in farm-
and household-reared swine. The biological material under study consisted of clinically healthy
swine of various ages. The animals originated from 4 distinct locations. Serological examinations
were carried out by blood sampling (from the jugular) before and after anti-erysipelas vaccination.
The tests were carried out by ELISA.
In farms, the anti PRRS antibody seroprevalence was high, unlike the low level of postvaccinal
anti-erysipelas antibodies. In households, PRRS virus incidence was low and seroconversion after
anti-erysipelas vaccination was high.
The pathological and bacteriological examinations carried out on various organs with lesions
(lungs, lymph nodes, liver, spleen, intestine) revealed the presence of pathogenic or potentially
pathogenic associated bacteria.
The results indicate a connection with PRRS virus in swine and the postvaccinal immune response,
the presence of which can significantly interfere with the efficacy of vaccination protocols.
The PRRS virus, the etiologic agent of the Porcine Respiratory and Reproductive Syndrome, due to
its immunosuppressive effect can significantly impair the postvaccinal immune response.
The immunological reaction induced by anti-erysipelas vaccination has been observed both in farm-
and household-reared swine. The biological material under study consisted of clinically healthy
swine of various ages. The animals originated from 4 distinct locations. Serological examinations
were carried out by blood sampling (from the jugular) before and after anti-erysipelas vaccination.
The tests were carried out by ELISA.
In farms, the anti PRRS antibody seroprevalence was high, unlike the low level of postvaccinal
anti-erysipelas antibodies. In households, PRRS virus incidence was low and seroconversion after
anti-erysipelas vaccination was high.
The pathological and bacteriological examinations carried out on various organs with lesions
(lungs, lymph nodes, liver, spleen, intestine) revealed the presence of pathogenic or potentially
pathogenic associated bacteria.
The results indicate a connection with PRRS virus in swine and the postvaccinal immune response,
the presence of which can significantly interfere with the efficacy of vaccination protocols.
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