Mycobacterium arupense
Taxonomy
Morphology
Cultural characteristics
Biochemical characters
Ecology
Pathogenicity
References
Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium,
Mycobacterium arupense Cloud et al. 2006.

Member of the
Mycobacterium terrae complex.
Acid-alcohol-fast rods.
Grows rapidly (5-7 days) on Lowenstein-Jensen medium at 30 ºC and slowly (10-12
days) at 37 ºC. Nonchromogenic. No growth on MacConkey agar without crystal violet
or on media supplemented with 5% (w/v) NaCl.  Grows at 22 ºC; does not grow at 42
or 45 ºC.
Isolated from a human tendon, bronchial washings, a finger wound, and sputum. Susceptible to ethambutol (2 µg/ml), clarithromycin
and rifabutin. Resistant to isoniazid (2 µg/ml) streptomycin (8 µg/ml - contradictory results), rifampin (32 µg/ml), linezolid, and
quinolones.
Affects immunosuppressed persons causing tensinovitis and respiratory infectins.
  1. John G. Magee and Alan C. Ward 2012. Family III. Mycobacteriaceae Chester 1897, 63AL in Bergey’s Manual of Systematic
    Bacteriology, Volume Five The Actinobacteria, Part A, Michael Goodfellow & al. (editors), 312-375.
  2. Cloud JL, Meyer JJ, Pounder JI, Jost KCJ, Sweeney A, Carroll KC, Woods GL. Mycobacterium arupense sp. nov., a non-
    chromogenic bacterium isolated from clinical specimens. Int J Syst Evol Microbiol 2006; 56:1413-1418.
  3. Lopez FK, Miley M, Taiwo B. Mycobacterium arupense as an Emerging Cause of Tenosynovitis. Emerg Infect Dis. 2016;22(3):559–
    561. doi:10.3201/eid2203.151479.
  4. Masaki T, Ohkusu K, Hata H, Fujiwara N, Iihara H, Yamada-Noda M, Nhung PH, Hayashi M, Asano Y, Kawamura Y, et al.
    Mycobacterium kumamotonense Sp. Nov. recovered from clinical specimen and the first isolation report of Mycobacterium
    arupense in Japan: Novel slowly growing, nonchromogenic clinical isolates related to Mycobacterium terrae complex. Microbiol
    Immunol 2006; 50:889-897.
Positive results for acid phosphatase, arylsulfatase (14 days), beta-galactosidase, thermostable catalase (68 ºC), and Tween 80
hydrolysis.

Negative results for arylsulfatase (3 days), cystine arylamidase, alpha- and beta-glucosidase, iron uptake, niacin production, nitrate
reduction, pyrazinamidase, and urease.
(c) Costin Stoica
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