Streptococcus sanguinis NCTC 7863
colonies on Sheep Blood Agar
Streptococcus sanguinis cells, Gram-staining
Streptococcus sanguinis
Positive results for arginine hydrolysis (most strains), leucine aminopeptidase, alpha-
maltosidase, alanyl-phenylalanyl-proline arylamidase, acid production from:
galactose, N-acetylglucosamine, fructose, glucose, maltose, mannose, lactose,
salicin, sucrose and trehalose.

Negative results for alkaline phosphatase, hippurate hydrolysis, urea hydrolysis,
Voges–Proskauer reaction, alpha-L-arabinosidase, alpha-L-fucosidase, alpha-D-
glucosidase, beta-maltosidase, alpha- or beta-mannosidases, beta-L-fucosidase,
beta-glucuronidase, beta-glucosaminidase, N-acetyl-alpha-D-glucosaminidase, N-
acetyl-beta-D-galactosaminidase, ornithine decarboxylase, lysine decarboxylase,
sialidase (neuraminidase), urease, alpha- or beta-xylosidases, acid production from:
adonitol, arabinose, arabitol, cyclodextrin, dulcitol, glycerol, gluconate, glycogen,
mannitol, D-melezitose, rhamnose, ribose, sorbose, tagatose and xylose.

Variable results for acid phosphatase, esculin hydrolysis, starch hydrolysis, beta-D-
glucosidase, alpha-D-galactosidase, beta-D-galactosidase, N-acetyl-beta-D-
glucosaminidase, chymotrypsin, beta-D-fucosidase, glycyl-tryptophan arylamidase,
beta-D-lactosidase, N-acetyl-beta-D-glucosaminidase, phospho-beta-galactosidase,
phosphoamidase, valine aminopeptidase, acid production from: amygdalin, arbutin,
D-cellobiose, esculin, inulin, melibiose, methyl D-glucoside, pullulan, raffinose,
sorbitol and starch.
Cultural characteristics
Biochemical characters
Phylum Firmicutes, Class Bacilli, Order Lactobacillales, Family Streptococcaceae, Genus Streptococcus, Streptococcus sanguinis  
(White and Niven 1946) Trüper and De' Clari 1997.

Old synonym:
Streptococcus sanguis  White and Niven 1946.
Lancefield group H or non-groupable.
Gram-positive cocci, 0.8-1.2 μm in diameter, grouped in short to  long chains,
nonmotile. May show occasional rod-shaped cells in aerobically growth cultures.
Most strains produce  alpha-hemolysis on blood agar (but one strain produced
narrow zone of beta-hemolysis) and pronounced greening on chocolate agar.
Matt or glossy type colonies may be produced, usually 0.7 to 0.9 mm in diameter on
blood agar after 48 hours at 37 ºC. Grow at 37 ºC, but not at 10 ºC; growth at 45 ºC is
variable. Fails to grow in presence of 6.5% NaCl or in skim milk containing 0.1 per
cent methylene blue. Most cultures grow on blood agar containing 40%  bile. Final pH
in glucose broth, between 4.6 and 5.2.
Isolated from the blood stream or "heart vegetation" of endocarditis in humans. Occasionally isolated from infected sinuses and teeth
and from house dust.
May be a cause of subacute bacterial endocarditis.
  1. Holt J.G., Krieg N.R., Sneath P.H.A., Staley J.T. and Williams S.T., 1994. Bergey's Manual of Determinative Bacteriology, Ninth
    Edition, Williams & Wilkins, A Waverly Company, Baltimore, pp 527-558.
  2. Robert A. Whiley and Jeremy M. Hardie, 2009. Genus I. Streptococcus Rosenbach 1884, 22AL. In: (Eds.) P.D. Vos, G. Garrity, D.
    Jones, N.R. Krieg, W. Ludwig, F.A. Rainey, K.-H. Schleifer, W.B. Whitman. Bergey’s Manual of Systematic Bacteriology, Volume 3:
    The Firmicutes, Springer, 655-711.
  3. Truper H.G. & De' Clari L.: Taxonomic note: Necessary correction of specific epithets formed as substantives (nouns) "in
    apposition". Int. J. Syst. Bacteriol., 1997, 47, 908-909.
  4. White J.C. & Niven Jr. C.F.: Streptococcus s.b.e.: a streptococcus associated with subacute bacterial endocarditis. Journal of
    Bacteriology, 1946, 51, 717-722.]
  5. Kilian M., Mikkelsen L. and Henrichsen J.: Taxonomic study of viridans streptococci: description of Streptococcus gordonii sp. nov.
    and emended descriptions of Streptococcus sanguis (White and Niven 1946), Streptococcus oralis (Bridge and Sneath 1982), and
    Streptococcus mitis (Andrewes and Horder 1906). Int. J. Syst. Bacteriol., 1989, 39, 471-484.
(c) Costin Stoica
Culture media
Biochemical tests
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