Mycobacterium shinjukuense
Taxonomy
Morphology
Cultural characteristics
Biochemical characters
Ecology
Pathogenicity
References
Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium,
Mycobacterium shinjukuense Saito et al. 2011.
Acid-alcohol-fast rods.
Colonies on 2% Ogawa egg medium are smooth and non-chromogenic. Growth is
observed following incubation for 21 days at 30-37 ºC; no growth at 25 or 45 ºC. No
growth in 5% NaCl media.
Isolated from sputum and bronchial lavage fluid samples in Japan and Korea.
Susceptible to isoniazide (0.2 / 1 µg/ml), rifampicin (40 µg/ml), ethambutol (2.5 µg/ml), levofloxacin (1 µg/ml), ethionamide (20 µg/ml),
kanamycin (20 µg/ml), cycloserine (30 µg/ml), and streptomycin (10 µg/ml). Resistant to paraaminosalicylic acid (1 µg/ml) and
eniviomycin (2.5 µg/ml).
Undetermined. Associated with lung disease.
  1. Saito H, Iwamoto T, Ohkusu K, Otsuka Y, Akiyama Y, Sato S, Taguchi O, Sueyasu Y, Kawabe Y, Fujimoto H, et al. Mycobacterium
    shinjukuense sp. nov., a slowly growing, non-chromogenic species isolated from human clinical specimens. Int J Syst Evol
    Microbiol 2011; 61:1927-1932.
  2. Watanabe K, Shinkai M, Yamaguchi N, Shinoda M, Hara Y, Ishigatsubo Y, Kaneko T. Mycobacterium shinjukuense lung disease
    that was successfully treated with antituberculous drugs. Intern Med. 2013;52(23):2653-5. doi: 10.2169/internalmedicine.52.1116.
    PMID: 24292757.
  3. Seong Mi Moon, Su-Young Kim, Myung Jin Chung, Seung Heon Lee, Sung Jae Shin, Won-Jung Koh. Nontuberculous
    Mycobacterial Lung Disease Caused by Mycobacterium shinjukuense: The First Reported Case in Korea Tuberc Respir Dis.
    2015;78(4):416-418.   Published online October 1, 2015 DOI: https://doi.org/10.4046/trd.2015.78.4.416
  4. Oshima K, Yokouchi H, Minemura H, Saito J, Tanino Y, Munakata M. Pulmonary infection caused by Mycobacterium shinjukuense.
    Ann Am Thorac Soc 2015;12:958-959. PMID: 26075560.
Positive results for thermo-stable catalase (68 ºC), nitrate reductase, pyrazinamidase and Tween 80 hydrolysis.

Negative results for arylsulfatase (3 days), semi-quantitative catalase, and urease.
(c) Costin Stoica
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