Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium, Mycobacterium lepraemurium Marchoux and Sorel 1912.
Strongly acid-fast irregular with slightly rounded ends, 3-5 μm in length rods.
Difficult cultivation. Dense compact inocula on Ogawa egg medium leads to the
growth ofrough, non-chromogenic colonies after incubation for 4-5weeks at 30-37 ºC.
Growth also occurs on agar-based media supplemented with cytochrome c and
alpha-ketoglutaric acid. No growth at 42 ºC. No growth on 5%(w/v) NaCl.
Source is unknown. Susceptible to hydroxylamine (500 mg/l).
Pathogenic to rats occuring mainly in the lymph nodes and skin. Produce induration, alopecia, and eventual ulceration.
- John G. Magee and Alan C. Ward 2012. Family III. Mycobacteriaceae Chester 1897, 63AL in Bergey’s Manual of Systematic
Bacteriology, Volume Five The Actinobacteria, Part A, Michael Goodfellow & al. (editors), 312-375.
- Rastogi N, Legrand E, Sola C. The mycobacteria: an introduction to nomenclature and pathogenesis. Rev Sci Tech. 2001;20(1):21‐
Positive results for pyrazinamidase activity (negative in Rastogi's paper).
Negative results for acid phosphatase, arylsulphatase (3, 7 and 10 days), heat-stable catalase, semiquantitative catalase test, nitrate
reduction, niacin production, nicotinamidase, Tween 80 and urea hydrolysis
Variable results for alpha-esterase activity.
(c) Costin Stoica