| Mycobacterium leprae |
Taxonomy
Morphology
Cultural characteristics
Biochemical characters
Ecology
Pathogenicity
References
Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium, Mycobacterium leprae (Hansen 1880) Lehmann and Neumann 1896.
Synonym: "Hansen’s bacillus".
Mycobacterium, Mycobacterium leprae (Hansen 1880) Lehmann and Neumann 1896.
Synonym: "Hansen’s bacillus".
Strongly acid-fast rods, 1.0-8.0 x 0.3-0.5 μm, with rounded ends and parallel sides
which stain evenly or sometimes are beaded. Cells are arranged in clumps, rounded
masses (globi) or in groups of bacilli aligned side by side.
which stain evenly or sometimes are beaded. Cells are arranged in clumps, rounded
masses (globi) or in groups of bacilli aligned side by side.
Not cultivable ‘in vitro’.
In vivo can be cultivate in mice. Bacilli from human leprous tissue multiply with an
apparent generation time of 20-30 days when inoculated into footpads of healthy
mice. No tuberculostearic acid is produced. Mycolic acids identified in M. leprae
resemble those of Mycobacterium gordonae.
In vivo can be cultivate in mice. Bacilli from human leprous tissue multiply with an
apparent generation time of 20-30 days when inoculated into footpads of healthy
mice. No tuberculostearic acid is produced. Mycolic acids identified in M. leprae
resemble those of Mycobacterium gordonae.
During cultivation in mice, the leprosy bacilli do not invade deep tissues and their multiplication can be inhibited by cycloserine,
diaminodiphenyl sulfone, isoniazid, p-aminosalicylic acid, and rifampin. Can multiply extensively in tissues of the nine-banded
armadillo (Dasypus novemcinctus).
diaminodiphenyl sulfone, isoniazid, p-aminosalicylic acid, and rifampin. Can multiply extensively in tissues of the nine-banded
armadillo (Dasypus novemcinctus).
Causes leprosy in man ("Hansen’s disease"). In the lepromatous form of the disease, cells are abundant in the tissue producing
stuffed-cell granulomas; in tuberculoid and neural lesions, organisms are rare. The incubation period ranges from 9 months to 20
years, usually 4 years for tuberculoid leprosy and 8 years for lepromatous leprosy.
stuffed-cell granulomas; in tuberculoid and neural lesions, organisms are rare. The incubation period ranges from 9 months to 20
years, usually 4 years for tuberculoid leprosy and 8 years for lepromatous leprosy.
- John G. Magee and Alan C. Ward 2012. Family III. Mycobacteriaceae Chester 1897, 63AL in Bergey’s Manual of Systematic
Bacteriology, Volume Five The Actinobacteria, Part A, Michael Goodfellow & al. (editors), 312-375. - Leprosy (Hansen's disease) - Blue Book - Department of Health and Human services, Victoria, Australia". https://www2.health.vic.
gov.au/public-health/infectious-diseases/disease-information-advice/leprosy#incubation. Accessed 2020-02-22.
During cultivation in mice, the leprosy bacilli do not invade deep tissues and their multiplication can be inhibited by cycloserine,
diaminodiphenyl sulfone, isoniazid, p-aminosalicylic acid, and rifampin. Can multiply extensively in tissues of the nine-banded
armadillo (Dasypus novemcinctus).
diaminodiphenyl sulfone, isoniazid, p-aminosalicylic acid, and rifampin. Can multiply extensively in tissues of the nine-banded
armadillo (Dasypus novemcinctus).
(c) Costin Stoica
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