| Mycobacterium intracellulare |
Taxonomy
Morphology
Cultural characteristics
Biochemical characters
Ecology
Pathogenicity
References
Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium, Mycobacterium intracellulare (Cuttino and McCabe 1949) Runyon 1965; 2 subspecies:
- Mycobacterium intracellulare subsp. intracellulare Castejon et al. 2018
- Mycobacterium intracellulare subsp. chimaera (Tortoli et al. 2004) Nouioui et al. 2018, synonyms: Mycobacterium intracellulare
subsp. yongonense Castejon et al. 2018, Mycobacterium yongonense Kim et al. 2013.
According to Nouioui et al. 2018, Mycobacterium paraintracellulare Lee et al. 2016 is a later heterotypic synonym of Mycobacterium
intracellulare (Cuttino and McCabe 1949) Runyon 1965. Replaces Mycobacterium intracellulare genotype 1 (INT-1).
Member of the Mycobacterium avium complex.
Old synonym: Nocardia intracellularis Cuttino and McCabe 1949.
Mycobacterium, Mycobacterium intracellulare (Cuttino and McCabe 1949) Runyon 1965; 2 subspecies:
- Mycobacterium intracellulare subsp. intracellulare Castejon et al. 2018
- Mycobacterium intracellulare subsp. chimaera (Tortoli et al. 2004) Nouioui et al. 2018, synonyms: Mycobacterium intracellulare
subsp. yongonense Castejon et al. 2018, Mycobacterium yongonense Kim et al. 2013.
According to Nouioui et al. 2018, Mycobacterium paraintracellulare Lee et al. 2016 is a later heterotypic synonym of Mycobacterium
intracellulare (Cuttino and McCabe 1949) Runyon 1965. Replaces Mycobacterium intracellulare genotype 1 (INT-1).
Member of the Mycobacterium avium complex.
Old synonym: Nocardia intracellularis Cuttino and McCabe 1949.
Acid-fast, short to long rods; transiently filamentous in new growth, eventually
becoming coccobacillary.
becoming coccobacillary.
Colonies after incubation at 37 ºC for 7 or more days are smooth, rarely rough and
non-pigmented (old cultures may become yellow). Grows at 22 ºC. Variable growth
at 45 ºC. No Growth on 5% (w/v) NaCl media or on MacConkey agar.
non-pigmented (old cultures may become yellow). Grows at 22 ºC. Variable growth
at 45 ºC. No Growth on 5% (w/v) NaCl media or on MacConkey agar.
Isolated from fatal systemic disease in a child. Frequently encountered in pulmonary secretions from individuals suffering from
tuberculosis-like disease. Subsp. chimera was isolataed from respiratory tract of elderly people.
Resistant to Ethambutol (2 mg/l) and Isoniazid (1 mg/l).
tuberculosis-like disease. Subsp. chimera was isolataed from respiratory tract of elderly people.
Resistant to Ethambutol (2 mg/l) and Isoniazid (1 mg/l).
Can produce pulmonary infections, but it is frequently isolated as an apparent casual resident.
- John G. Magee and Alan C. Ward 2012. Family III. Mycobacteriaceae Chester 1897, 63AL in Bergey’s Manual of Systematic
Bacteriology, Volume Five The Actinobacteria, Part A, Michael Goodfellow & al. (editors), 312-375. - Loredana Gabriela Popa, Mircea Ioan Popa 2009. Identificarea bacililor acido-rezistenti in: Tratat de microbiologie clinica, Dumitru
Buiuc, Marian Negut, ed. a III-a, Editura Medicala, 881-890, ISBN (13) 978-973-39-0593-6. - Castejon, M., Menendez, M. C., Comas, I., Vicente, A. And Garcia, M. J. 2018. Whole-genome sequence analysis of the
Mycobacterium avium complex and proposal of the transfer of Mycobacterium yongonense to Mycobacterium intracellulare subsp.
yongonense subsp. nov. Int. J. Syst. Evol. Microbiol., 68, 1998-2005. - Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M. Genome-
Based Taxonomic Classification of the Phylum Actinobacteria. Front Microbiol 2018; 9:2007. - Tortoli E, Rindi L, Garcia MJ, Chiaradonna P, Dei R, Garzelli C, Kroppenstedt RM, Lari N, Mattei R, Mariottini A, et al. Proposal to
elevate the genetic variant MAC-A, included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp.
nov. Int J Syst Evol Microbiol 2004; 54:1277-1285. - M. Tsukamura. Numerical Classification of Slowly Growing Mycobacteria. International Journal of Systematic Bacteriology, Oct.
1976, p. 409-420. - I. B. Salah, C. Cayrou, D. Raoult, and M. Drancourt, Mycobacterium marseillense sp. nov., Mycobacterium timonense sp. nov. and
Mycobacterium bouchedurhonense sp. nov.,members of the Mycobacterium avium complex. International Journal of Systematic
and Evolutionary Microbiology, vol. 59, no. 11, pp. 2803-2808, 2009.
M. intracellulare and M. avium, including subspecies, are difficult to be differentiated by biochemical tests.
Positive results for catalase (inactivated at 68 ºC), alpha-esterase, pyrazinamidase, arylsulphatase (3 and 10 days) and tellurite
reduction.
Negative results for acid phosphatase, semiquantitative catalase test, beta-galactosidase, niacin production, nitrate reduction, Tween
80 hydrolysis, urease, citrate and succinate utilization in the presence of ammoniac nitrogen.
Positive results for catalase (inactivated at 68 ºC), alpha-esterase, pyrazinamidase, arylsulphatase (3 and 10 days) and tellurite
reduction.
Negative results for acid phosphatase, semiquantitative catalase test, beta-galactosidase, niacin production, nitrate reduction, Tween
80 hydrolysis, urease, citrate and succinate utilization in the presence of ammoniac nitrogen.
(c) Costin Stoica
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Legend: +,90% or more of strains are positive; − 90% or more of strains are negative; v variable/weak, * species included in M. avium