Mycobacterium frederiksbergense
Taxonomy
Morphology
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Pathogenicity
References
Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium,
Mycobacterium frederiksbergense Willumsen et al. 2001.
Acid-fast, coccoid to short rods. Gram-positive. Branching is not observed.
Colonies are smooth, cadmium yellow, and scotochromogenic after incubation for 5
days on trypticase soy broth and Middlebrook 7H10 agar. The temperature range for
growth is 15-37 ºC; optimal growth occurs at 30 ºC. No growth at 42 or 45 ºC.
No growth on MacConkey agar (without crystal violet).
Initially isolated from the site of a former gas works at Frederiksberg, Denmark. Later isolated from Alfalfa plants and tap water. One
report of isolation from farmed sea bream (
Sparus aurata). One isolate from a catheter-related bloodstream infection in a child.
Can produce pale skin, dorsal fin necrosis, and a significant level of mortality (40%) in sea bream (Sparus aurata).
Reported catheter-related bloodstream infection in an immunocompromised child.
  1. John G. Magee and Alan C. Ward 2012. Family III. Mycobacteriaceae Chester 1897, 63AL in Bergey’s Manual of Systematic
    Bacteriology, Volume Five The Actinobacteria, Part A, Michael Goodfellow & al. (editors), 312-375.
  2. Willumsen P, Karlson U, Stackebrandt E, Kroppenstedt RM. Mycobacterium frederiksbergense sp. nov., a novel polycyclic
    aromatic hydrocarbon-degrading Mycobacterium species. Int J Syst Evol Microbiol 2001; 51:1715-1722.
  3. Mousaviehzadeh, M. and Sardari, S. (2015) Susceptibility Testing of Mycobacterium frederiksbergense Strains Isolated from
    Alfalfa Plants against Antibacterial Compounds. Open Journal of Medical Microbiology, 5, 90-96. doi: 10.4236/ojmm.2015.52011.
  4. Masoud Keikha. Isolation of Mycobacterium frederiksbergense From Redundant Tap Water: A Case Report. Avicenna J Environ
    Health Eng 2017/12/20;4(2):35-37.
  5. Urku, Cigdem et al. “Mycobacteriosis in Farmed Sea Bream (Sparus aurata) Caused By Mycobacterium frederiksbergense in
    Turkey.” Acta Veterinaria-beograd 68 (2018): 391-400.
  6. Senozan EA, Adams DJ, Giamanco NM, Warwick AB, Eberly MD. A catheter-related bloodstream infection with Mycobacterium
    frederiksbergense in an immunocompromised child. The Pediatric Infectious Disease Journal. 2015 Apr;34(4):445-447. DOI:
    10.1097/inf.0000000000000563.
Degrades polycyclic aromatic hydrocarbons.

Positive results for catalase, nitrate reduction, Tween 80 hydrolysis
Can utilize N-acetyl D-glucosamine, D-glucosaminic acid, D-rhamnose, succinate, 2-hydroxyvalerate, gluconate, i-inositol, putrescine,
p-nitrophenyl beta-D-xyloside and mannitol.

Negative results for urea hydrolysis.
No utilization of  acetamide, phenylacetic acid, L-alanine, D-arabitol, L-aspartate, benzoate, 4-aminobenzoate, 4-hydroxybenzoate,
citrate, glutarate, 2-oxoglutarate, L-leucine, L-proline, putrescine, quinate, D-ribose, sucrose, D-turanose and L-valine.
(c) Costin Stoica
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