Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium, Mycobacterium frederiksbergense Willumsen et al. 2001.
Acid-fast, coccoid to short rods. Gram-positive. Branching is not observed.
Colonies are smooth, cadmium yellow, and scotochromogenic after incubation for 5
days on trypticase soy broth and Middlebrook 7H10 agar. The temperature range for
growth is 15-37 ºC; optimal growth occurs at 30 ºC. No growth at 42 or 45 ºC.
No growth on MacConkey agar (without crystal violet).
Initially isolated from the site of a former gas works at Frederiksberg, Denmark. Later isolated from Alfalfa plants and tap water. One
report of isolation from farmed sea bream (Sparus aurata). One isolate from a catheter-related bloodstream infection in a child.
Can produce pale skin, dorsal fin necrosis, and a significant level of mortality (40%) in sea bream (Sparus aurata).
Reported catheter-related bloodstream infection in an immunocompromised child.
- John G. Magee and Alan C. Ward 2012. Family III. Mycobacteriaceae Chester 1897, 63AL in Bergey’s Manual of Systematic
Bacteriology, Volume Five The Actinobacteria, Part A, Michael Goodfellow & al. (editors), 312-375.
- Willumsen P, Karlson U, Stackebrandt E, Kroppenstedt RM. Mycobacterium frederiksbergense sp. nov., a novel polycyclic
aromatic hydrocarbon-degrading Mycobacterium species. Int J Syst Evol Microbiol 2001; 51:1715-1722.
- Mousaviehzadeh, M. and Sardari, S. (2015) Susceptibility Testing of Mycobacterium frederiksbergense Strains Isolated from
Alfalfa Plants against Antibacterial Compounds. Open Journal of Medical Microbiology, 5, 90-96. doi: 10.4236/ojmm.2015.52011.
- Masoud Keikha. Isolation of Mycobacterium frederiksbergense From Redundant Tap Water: A Case Report. Avicenna J Environ
Health Eng 2017/12/20;4(2):35-37.
- Urku, Cigdem et al. “Mycobacteriosis in Farmed Sea Bream (Sparus aurata) Caused By Mycobacterium frederiksbergense in
Turkey.” Acta Veterinaria-beograd 68 (2018): 391-400.
- Senozan EA, Adams DJ, Giamanco NM, Warwick AB, Eberly MD. A catheter-related bloodstream infection with Mycobacterium
frederiksbergense in an immunocompromised child. The Pediatric Infectious Disease Journal. 2015 Apr;34(4):445-447. DOI:
Degrades polycyclic aromatic hydrocarbons.
Positive results for catalase, nitrate reduction, Tween 80 hydrolysis
Can utilize N-acetyl D-glucosamine, D-glucosaminic acid, D-rhamnose, succinate, 2-hydroxyvalerate, gluconate, i-inositol, putrescine,
p-nitrophenyl beta-D-xyloside and mannitol.
Negative results for urea hydrolysis.
No utilization of acetamide, phenylacetic acid, L-alanine, D-arabitol, L-aspartate, benzoate, 4-aminobenzoate, 4-hydroxybenzoate,
citrate, glutarate, 2-oxoglutarate, L-leucine, L-proline, putrescine, quinate, D-ribose, sucrose, D-turanose and L-valine.
(c) Costin Stoica