| Mycobacterium caprae |
Taxonomy
Morphology
Cultural characteristics
Biochemical characters
Ecology
Pathogenicity
References
Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium, Mycobacterium caprae (Aranaz et al. 1999) Aranaz et al. 2003.
Member of the Mycobacterium tuberculosis complex.
Old synonyms: Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999, Mycobacterium bovis subsp. caprae (Aranaz et al.
1999) Niemann et al. 2002
According to Riojas et al. (2018), M. caprae is a later heterotypic synonym of Mycobacterium tuberculosis (Zopf 1883) Lehmann and
Neumann 1896.
Mycobacterium, Mycobacterium caprae (Aranaz et al. 1999) Aranaz et al. 2003.
Member of the Mycobacterium tuberculosis complex.
Old synonyms: Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999, Mycobacterium bovis subsp. caprae (Aranaz et al.
1999) Niemann et al. 2002
According to Riojas et al. (2018), M. caprae is a later heterotypic synonym of Mycobacterium tuberculosis (Zopf 1883) Lehmann and
Neumann 1896.
Acid-alcohol-fast rods, with weak cord formation. Nonspore-forming. Nonmotile.
Colonies are smooth and non-chromogenic after incubation at 36 ºC for 4-6 weeks.
Growth is enhanced by pyruvate. Does not grow at 22, 30, or 45 ºC, or on media
supplemented with 5% (w/v) NaCl.
Growth is enhanced by pyruvate. Does not grow at 22, 30, or 45 ºC, or on media
supplemented with 5% (w/v) NaCl.
Isolated from the lymph nodes and lungs of tuberculous goats and from cattle, red deer, pigs, sheep, and wild boars and from a captive
Siberian tiger. Also isolated from human sputum.
Susceptible to hydroxylamine (500 μg/ml). Resistant to 1 and 2 μg/ml tiophene-2-carboxylic acid hydrazide (TCH) but not to 5 or 10
μg/ml TCH. Also susceptible to streptomycin, isoniazid, rifampicin, ethambutol and pyrazinamide.
Siberian tiger. Also isolated from human sputum.
Susceptible to hydroxylamine (500 μg/ml). Resistant to 1 and 2 μg/ml tiophene-2-carboxylic acid hydrazide (TCH) but not to 5 or 10
μg/ml TCH. Also susceptible to streptomycin, isoniazid, rifampicin, ethambutol and pyrazinamide.
Produce tuberculosis in goats. Has also been found as a pathogen in humans linked with goat farming.
- John G. Magee and Alan C. Ward 2012. Family III. Mycobacteriaceae Chester 1897, 63AL in Bergey’s Manual of Systematic
Bacteriology, Volume Five The Actinobacteria, Part A, Michael Goodfellow & al. (editors), 312-375. - Riojas MA, McGough KJ, Rider-Riojas CJ, Rastogi N, Hazbon MH. Phylogenomic analysis of the species of the Mycobacterium
tuberculosis omplex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium
microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis. Int J Syst Evol Microbiol
2018; 68:324-332. - Aranaz, A., E. Liebana, E. Gomez-Mampaso, J.C. Galan, D. Cousins, A. Ortega, J. Blazquez, F. Baquero, A. Mateos, G. Suarez and
L. Dominguez. 1999. Mycobacterium tuberculosis subsp. caprae subsp. nov.: a taxonomic study of a new member of the
Mycobacterium tuberculosis complex isolated from goats in Spain. Int. J. Syst. Bacteriol. 49: 1263–1273. - Aranaz, A., D. Cousins, A. Mateos and L. Dominguez. 2003. Elevation of Mycobacterium tuberculosis subsp. caprae Aranaz et al.
1999 to species rank as Mycobacterium caprae comb. nov., sp. nov. Int. J. Syst. Evol.Microbiol. 53: 1785–1789. - Prodinger, W.M., A. Eigentler, F. Allerberger, M. Schonbauer and W. Glawischnig. 2002. Infection of red deer, cattle, and humans
with Mycobacterium bovis subsp. caprae in western Austria. J. Clin. Microbiol. 40: 2270–2272. - Kozinska M, Krajewska-Wędzina M, Augustynowicz-Kopec E. Mycobacterium caprae – the first case of the human infection in
Poland. Ann Agric Environ Med. 2020;27(1):151-153. doi:10.26444/aaem/108442.
Positive result for acid and alkaline phosphatase, Tween 80 hydrolysis (weak reaction).
Negative results for arylsulfatase activity (at 3, 7 and 10 days), catalase (inactivated at 68°C), nitrate reduction, niacin production and
pyrazinamidase.
Variable results for urea hydrolysis and tellurite reduction.
Negative results for arylsulfatase activity (at 3, 7 and 10 days), catalase (inactivated at 68°C), nitrate reduction, niacin production and
pyrazinamidase.
Variable results for urea hydrolysis and tellurite reduction.
(c) Costin Stoica
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