| Mycobacterium asiaticum |
Taxonomy
Morphology
Cultural characteristics
Biochemical characters
Ecology
Pathogenicity
References
Phylum Actinobacteria, Class Actinobacteria, Order Actinomycetales, Suborder Corynebacterineae, Family Mycobacteriaceae, Genus
Mycobacterium, Mycobacterium asiaticum Weiszfeiler et al. 1971.
Mycobacterium, Mycobacterium asiaticum Weiszfeiler et al. 1971.
Acid-fast, coccoid rods. No cording. No cross-barring.
Colonies are dysgonic, smooth and yellow-orange after incubation for 15-21 days at
37 ºC. Can grow at 42 ºC, but not at 45 ºC. Strains are usually photochromogenic, but
occasionally fail to develop pigment after exposure to light (14%); pigment is not
produced in the dark. No growth at 22 ºC, weak growth at 25 ºC. No growth on media
supplemented with 5% (w/v) NaCl or on MacConkey agar without crystal violet.
37 ºC. Can grow at 42 ºC, but not at 45 ºC. Strains are usually photochromogenic, but
occasionally fail to develop pigment after exposure to light (14%); pigment is not
produced in the dark. No growth at 22 ºC, weak growth at 25 ºC. No growth on media
supplemented with 5% (w/v) NaCl or on MacConkey agar without crystal violet.
Original strains were isolated from monkeys, but few strains were isolated human sputum specimens and bronchial washings.
Resistant to rifampin (25 μg/ml), hydroxylamine (500 µg/ml), ethambutol (5 µg/ml) and tiophene-2-carboxylic acid hydrazide (1 µg/ml).
Resistant to rifampin (25 μg/ml), hydroxylamine (500 µg/ml), ethambutol (5 µg/ml) and tiophene-2-carboxylic acid hydrazide (1 µg/ml).
May produce human pulmonary disease. It is often a colonizer or contaminant, but can be responsible for pulmonary disease
including noncavitary disease. It can also be responsible for childhood lymphadenitis and soft tissue infections.
Experimental infection: produces focal lung lesions after intravenous inoculation of mice; may kill mice within 30-60 days.
including noncavitary disease. It can also be responsible for childhood lymphadenitis and soft tissue infections.
Experimental infection: produces focal lung lesions after intravenous inoculation of mice; may kill mice within 30-60 days.
- John G. Magee and Alan C. Ward 2012. Family III. Mycobacteriaceae Chester 1897, 63AL in Bergey’s Manual of Systematic
Bacteriology, Volume Five The Actinobacteria, Part A, Michael Goodfellow & al. (editors), 312-375. - Loredana Gabriela Popa, Mircea Ioan Popa 2009. Identificarea bacililor acido-rezistenti in: Tratat de microbiologie clinica, Dumitru
Buiuc, Marian Negut, ed. a III-a, Editura Medicala, 881-890, ISBN (13) 978-973-39-0593-6. - Miriam Grech, Robyn Carter, and Rachel Thomson. Clinical Significance of Mycobacterium asiaticum Isolates in Queensland,
Australia. Journal of Clinical Microbiology, Jan. 2010, p. 162-167, doi:10.1128/JCM.01602-09. - Meier A, Kirschner P, Schroder KH, Wolters J, Kroppenstedt RM, Bottger EC. Mycobacterium intermedium sp. nov. Int J Syst
Bacteriol 1993; 43:204-209. - Rastogi N, Legrand E, Sola C. The mycobacteria: an introduction to nomenclature and pathogenesis. Rev Sci Tech. 2001;20(1):21‐
54. doi:10.20506/rst.20.1.1265. - Tsukamura M. Numerical identification of slowly growing mycobacteria. Microbiol Immunol. 1985;29(11):1039‐1050. doi:10.1111/j.
1348-0421.1985.tb00894.x - Attorri S, Dunbar S, Clarridge JE 3rd. Assessment of morphology for rapid presumptive identification of Mycobacterium tuberculosis
and Mycobacterium kansasii. J Clin Microbiol. 2000;38(4):1426‐1429. - Kim BJ, Hong SH, Kook YH, Kim BJ. Mycobacterium paragordonae sp. nov., a slowly growing, scotochromogenic species closely
related to Mycobacterium gordonae. Int J Syst Evol Microbiol 2014; 64:39-45.
Positive results for acid phosphatase, alpha- and beta-esterase, arylsulfatase (10 days; negative at 3 days), catalase (inactivated at
68°C), semi-quantitative catalase test, and Tween 80 hydrolysis. Can utilize as sole carbon source glucose and pyruvate.
Negative results for beta-galactosidase, nitrate reduction, niacin production, nicotinamidase, and urea hydrolysis.
No utilization as sole carbon source of acetate, citrate, succinate, malate, benzoate, glucose, fructose, sucrose ethanol, and propanol.
Variable results for pyrazinamidase and tellurite reduction.
68°C), semi-quantitative catalase test, and Tween 80 hydrolysis. Can utilize as sole carbon source glucose and pyruvate.
Negative results for beta-galactosidase, nitrate reduction, niacin production, nicotinamidase, and urea hydrolysis.
No utilization as sole carbon source of acetate, citrate, succinate, malate, benzoate, glucose, fructose, sucrose ethanol, and propanol.
Variable results for pyrazinamidase and tellurite reduction.
(c) Costin Stoica
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