Phylum Proteobacteria, Class Epsilonproteobacteria, Order Campylobacterales, Family Helicobacteraceae, Genus Helicobacter,
Helicobacter bizzozeronii Hanninen et al. 1996.
Gram-negative, tightly coiled helical rods, 0.3 x 5–10 μm. Coccoid forms are observed
in old cultures. Rapid, corkscrew-like motility by means of multiple sheathed flagella
in a bipolar arrangement.
Culture of the bacteria is difficult and best achieved on freshly prepared, moist media.
Brucella agar does not support the growth. Individual colonies haven't been observed
and bacterial growth appears as a thin spreading film on agar media. Do not grow on
medium containing 1.5% NaCl. Grow at 37 and 42 ºC (variable) but not at 25 ºC. Most
strains (80%) are resistant to 5-fluorouracil (100 U/l), but do not grow in the presence
of 1% bile or metronidazole (4 mg/l).
Isolated from the canine gastric mucosa of healthy animals, and those showing signs of upper gastrointestinal dysfunction (vomiting
or abdominal discomfort). One strain isolated from a gastric biopsy of a human with gastritis.
Undetermined. May be associated with gastritis.
- George M. Garrity, Julia A. Bell and Timothy Lilburn, 2001. Family II. Helicobacteraceae. In: Bergey’s Manual of Systematic
Bacteriology, Second edition, Vol 2, part C, George M. Garrity (Editor-in-Chief), pp 1168-1195.
- Marja-Liis Hanninen, I. Happonen, S. Saari, and K. Jalava. Culture and Characteristics of Helicobacter bizzozeronii, a New
Canine Gastric Helicobacter sp. Int J Syst Bacteriol January 1996 46:160-166.
H. felis, H. bizzozeronii, and H. salomonis are biochemically and 16S rRNA gene sequence very similar.
Positive results for catalase, oxidase, urease (may be lost after subcultivation), nitrate reduction & gamma-glutamyl transpeptidase.
Negative results for growth in 1% glycine, tolerance and reduction of 0.04% TTC, hippurate hydrolysis, pyrrolidonyl arylamidase,
L-arginine arylamidase & L-aspartate arylamidase.
Variable results for indoxyl acetate hydrolysis & alkaline phosphatase.
(c) Costin Stoica