The immunosuppressive impact of PRRS virus on the immune response
following anti-erysipelas vaccination in swine from various farms

Viorica Chiurciu, Costin Stoica, Maria Mioara Răduţă, Cătălin Tudoran,
Diaconu Lucia, Ion Iacob

SC Romvac Company SA, Voluntari, Romania
Abstract

 The PRRS virus, the etiologic agent of the Porcine Respiratory and Reproductive
Syndrome, due to its immunosuppressive effect can significantly impair the
postvaccinal immune response.
 The immunological reaction induced by anti-erysipelas vaccination has been
observed both in farm- and household-reared swine. The biological material under
study consisted of clinically healthy swine of various ages. The animals originated from
4 distinct locations. Serological examinations were carried out by blood sampling (from
the jugular) before and after anti-erysipelas vaccination. The tests were carried out by
ELISA.
 In farms, the anti PRRS antibody seroprevalence was high, unlike the low level of
postvaccinal anti-erysipelas antibodies. In households, PRRS virus incidence was low
and seroconversion after anti-erysipelas vaccination was high.
 The pathological and bacteriological examinations carried out on various organs with
lesions (lungs, lymph nodes, liver, spleen, intestine) revealed the presence of
pathogenic or potentially pathogenic associated bacteria.
 The results indicate a connection with PRRS virus in swine and the postvaccinal
immune response, the presence of which can significantly interfere with the efficacy of
vaccination protocols.
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