Phylum Actinobacteria, Class Actinobacteria, Subclass Actibacteridae, Order Actynomycetales, Suborder Corynebacterinae, Family
Corynebacteriaceae, Genus Corynebacterium, Corynebacterium resistens Otsuka, Kawamura, Koyama, Iihara, Ohkusu and Ezaki
Gram-positive typically club-shaped rods, 1-3 µm in length, and that occur as single
cells, in pairs or in small clusters. Non-motile. Non-spore-forming.
Colonies are grayish-white, glistening, pearly, and up to 1 mm in diameter after 48 h
of incubation on 5% sheep blood TSA; Tween 80 enhanced growth, resulting in
colonies 2 to 4 mm in diameter. CAMP-negative. Non-hemolytic. Very slow growing
under anaerobic conditions.
Isolated from human blood, bronchial aspirate and abscess specimens. Multi-drug resistant: four of the five strains isolated were
highly resistant to antimicrobial agents, including beta-lactams, aminoglycosides, macrolides, quinolones, and tetracyclines.
Isolated from human blood, bronchial aspirate and abscess specimens. In immunocompromised patients, bacteremia associated
with this organism was rapidly fatal. The potential for nosocomial spread increases the clinical significance of isolates.
- Otsuka Y., Kawamura Y., Koyama T., Iihara H., Ohkusu K. and Ezaki T., 2005. Corynebacterium reistens sp. nov., a new multidrug-
resistant coryneform bacterium isolated from human infections. J. Clin. Microbiol. Vol. 43, No. 8, p. 3713-3717.
Description is based on API CORYNE (4100004), API 50CH and API ZYM results.
Positive results for acid phosphatase, alkaline phosphatase, catalase, ester lipase (C8), esterase (C4), cysteine arylamidase (weak
reaction), leucine arylamidase, lipophilic reaction, lipase (weak reaction), pyrrolidonyl arylamidase, acid production from: glucose,
5-ketogluconate, ribose & tagatose.
Negative results for esculin hydrolysis, gelatin hydrolysis, alpha- and beta-galactosidase, alpha- and beta-glucosidase,
beta-glucuronidase, N-acetyl-beta-glucosaminidase, nitrate reduction, oxidase, pyrazinamidase, trypsin, chymotrypsin, urease, valine
arylamidase, acid production from: adonitol, amygdalin, L-arabinose, arabitol, arbutin, cellobiose, dulcitol, erythritol, fructose,
galactose, L- and D-fucose, gentiobiose, glycerol, glycogen, gluconate, 2-ketogluconate, N-acetyl-beta-glucosamine, inositol, inulin,
lactose, lyxose, maltose, mannitol, mannose, melibiose, melezitose, raffinose, rhamnose, salicin, sorbitol, starch, sucrose, xylitol &
Variable results for acid production from L- sorbose & trehalose.
(c) Costin Stoica