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Phylum Actinobacteria, Class Actinobacteria , Subclass Actibacteridae, Order Actynomycetales, Suborder Corynebacterinae, Family
Corynebacteriaceae, Genus Corynebacterium,
Corynebacterium pseudodiphthericum Lehmann and Neumann 1986.

Historical synonyms:
Bacillus pseudodiphtheriticus (Lehmann and Neumann 1896) Kruse 1896, Bacterium pseudodiphtheriticum
(Lehmann and Neumann 1896) Migula 1900,
Mycobacterium pseudodiphthericum (Lehmann and Neumann 1896) Chester 1901,
Corynebacterium pseudodiphthericum (Lehmann and Neumann 1896) Bergey et al. 1925.
Gram-positive, short, regular rods, 0.5-2.0 x 0.3-0.5 µm. Nonmotile. Nonsporing.
Colonies are slightly dry, 1-2 mm in diameter after 48 h of incubation at 37 ºC. On
blood agar, colonies are white to cream and smooth. Hemolysis is not produced.
CAMP reaction is negative. Aerobic and facultatively anaerobic. Good growth on all
media.
Is part of the normal oropharyngeal bacterial flora. It might be recovered from exudate of patients with suspected diphtheria.
Susceptible to beta-lactams, aminoglycosides, ciprofloxacin, rifampin, and tetracycline. Resistant to macrolides and clindamycin.
Is associated mainly with respiratory disease and less commonly with endocarditis, prostheses or wound infections or colonizations
Most of the reported respiratory diseases occurred in immunosuppressed hosts.
It may also cause pneumonia or bronchitis in nonimmunocompromised hosts.
  1. Funke G., von Graevenitz A., Clarridge III J.E., and Bernard K.A., 1997. Clinical Microbiology of Coryneform Bacteria. Clinical
    Microbiology Rewiews Vol. 10, No. 1, p. 125-159.
  2. Funke G ., 2006.Corynebacteria and rare coryneforms. In: Topley & Wilson’s Microbiology & Microbial Infections, 10th Edition, Edited
    by Borriello S.P., Murray P.R. and Funke G.,Edward Arnold (Publishers) Ltd., Bacteriology, volume 2.
  3. Holt J.G., Krieg N.R., Sneath P.H.A., Staley J.T. and Williams S.T., 1994. Bergey's Manual of Determinative Bacteriology, Ninth
    Edition, Williams & Wilkins, A Waverly Company, Baltimore, pp 571-596.
  4. Cummins C.S., Lelliott R.A. and Rogosa M., 1975. Genus Corynebacterium Lehmann and Neumann 1896 . In: Buchanan R.E. and
    Gibbons N.E. (Editors), Bergey’s Manual of Determinative Bacteriology, Eight Edition, The Williams & Wilkins Company, Baltimore,
    602-617.
Not acid fast. Oxidative metabolism.

Positive results for hippurate hydrolysis, nitrate reduction, pyrazinamidase & urease.

Negative results for casein hydrolysis, esculin hydrolysis, gelatine hydrolysis, lipophilism, methyl red, acid production from: arabinose,
dextrin, fructose, galactose, glucose, lactose, maltose, mannitol, mannose, raffinose, rhamnose, salicin, starch, sucrose, trehalose &
xylose.

Variable results for alkaline phosphatase & tyrosine hydrolysis.
Corynebacterium pseudodiphthericum
(c) Costin Stoica
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