Actinomyces neuii
Taxonomy
Morphology
Cultural characteristics
Biochemical characters
Ecology
Pathogenicity
References
Phylum Actinobacteria, Class Actinobacteria, Subclass Actibacteridae, Order Actynomycetales, Suborder Actinomycinae, Family
Actinomycetaceae, Genus Actinomyces,
- Actinomyces neuii subsp. anitratus, Funke, Stubbs, von Graevenitz and Collins 1994.
- Actinomyces neuii subsp. neuii, Funke, Stubbs, von Graevenitz and Collins 1994.

Historical synonyms: CDC coryneform group 1, atypical CDC A-4 strains ( for
A. neuii
subsp. neuii
) and CDC coryneform group 1-like (for A. neuii subsp. anitratus).
Gram-positive diphtheroidal rods, arranged in clusters or V/Y forms, and coccobacilli.
Non-spore-forming. Non-motile.
Colonies are smooth, convex, opaque, whitish, 0.5-1.5 mm in diameter after 48 h of
incubation, 5% CO
2, on sheep blood agar. Subsp. neuii is alpha-haemolytic on sheep
blood agar (most strains) and on human blood agar.
Subsp. anitratus is not
haemolytic. Facultative anaerobic. Grows at 37 ºC. CAMP test is positive.
Isolated mainly from human clinical samples (absceses, skin lesions, genitourinary infections, endophthalmitis).
Susceptible to beta-lactams, clindamycin, vancomycin, erythromycin, rifampin, and tetracycline.
Cause human endophthalmitis. One case of a fatal septicaemia reported. Isolated mainly from abscesses (genitourinary infections,
skin lesions)  in association with mixed anaerobic flora and from human blood culture.
  1. Funke G., Stubbs S., von Graevenitz, and Collins M. D., 1994. Assignment of Human-Derived CDC Group 1 Coryneform Bacteria
    and CDC Group 1-Like Coryneform Bacteria to the Genus Actinomyces as Actinomyces neuii subsp. neuii sp. nov., subsp. nov.,
    and Actinomyces neuii subsp. anitratus subsp. nov. Int. J. Syst. Bacteriol. Vol. 44, No. 1, 167-171.
  2. Funke G., von Graevenitz A., Clarridge III J.E., and Bernard K.A., 1997. Clinical Microbiology of Coryneform Bacteria. Clinical
    Microbiology Rewiews Vol. 10, No. 1, p. 125-159.
Description is based on API 50CH, 5 days, and API CORYNE (code 2410735, 2510735, and 3410735)

Positive results for catalase, alpha- and beta-galactosidase, alpha-glucosidase, alpha-mannosidase, leucine arylamidase,
pyrazinamidase, acid production from: D-arabitol, erythritol, D-fructose, D-galactose, D-glucose, glycerol, 5-ketogluconate, inositol,
lactose, D-lyxose, maltose, D-mannitol, D-mannose, melezitose, melibiose, raffinose, D-ribose, sucrose, trehalose & D-xylose.

Negative results for acid phosphatase, esculin hydrolysis, gelatin hydrolysis, beta-glucosidase, beta-glucuronidase, urease, trypsin,  
chymotrypsin, valine arylamidase, acid production from: D-arabinose, 2-ketogluconate, L-rhamnose, L-sorbose & L-xylose.

Variable results for acid production from: L-arabitol, cellobiose, dulcitol, L- and D-fucose, gluconate, gentiobiose, glycogen,
N-acetylglucosamine & D-tagatose.
(c) Costin Stoica
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Legend: +  positive, - negative, v variable.
 
Nitrate
reduction
Alkaline
phosphatase
Adonitol
fermentation
L-arabinose
fermentation
Salicin
fermentation
Xylitol
fermentation
Inulin
fermentation
Alpha-methyl-
D-glucoside
fermentation
Alpha-methyl-
D-mannoside
fermentation
Subsp. anitratus
-
v
+
-
v
-
-
+
-
Subsp. neuii
+
-
v
v
-
v
v
v
v
Differential characters of the subspecies: